As the season continues and your character strengthens, shift your attention to Nightmare Dungeons and the Horadric Vault. Both of these locations scale with difficulty and reward players with stronger enemies and more abundant loot. Higher-level content means more elite foes, and with that comes a higher drop rate of Diablo IV gold vials and access to rare chests.

Once you've unlocked high-end content, the Horadric Fortress becomes a prime location for potion farming and vial collection. This area is rich in both enemy density and loot quality, making it an essential spot for players looking to power up quickly.

Additionally, Horadric Vials can be found in chests and stashes opened throughout the season. Leveling up quickly using the Whispering Tree will improve the quality of loot, including the vials you find.

Horadric Knowledge and Horadric Focus
By fighting in Helltides, completing Nightmare Dungeons, and exploring the Horadric Vault, you’ll also earn Horadric Knowledge. This knowledge allows you to unlock Horadric Focus rewards, which often contain large stashes of Horadric Vials and other essential spell components.

How to Use Horadric Vials Wisely
Horadric Vials are used exclusively to upgrade Horadric spells. However, it’s strongly recommended not to use too many early on. As your character progresses, you’ll unlock a wide range of Diablo 4 Items for sale spells and upgradeable components. Spending vials too soon may lead to enhancing spells you later abandon.